1、复杂抗癌天然产物的全合成

2、基于复杂天然产物结构的药物化学

3、基于复杂天然产物靶点的药物化学

2011.6 获山东大学理学学士学位

2011.9-2013.9 BETVLCTOR伟德在线登录平台 药学院 药物化学专业 硕转博（导师：陈悦）

2013.9-2016.7 BETVLCTOR伟德在线登录平台 BETVlCTOR登录网站 有机化学专业 博士（导师：汤平平） 

2016.7-2018.12 BETVLCTOR伟德在线登录平台药学院 讲师

2018.12-2020.10 BETVLCTOR伟德在线登录平台药学院 副教授

2020.10-今 BETVlCTOR登录网站 副教授

国家自然科学基金青年项目：低氧靶向的抗胰腺癌天然产物BE-43547A2的构效关系研究 2018.1-2020.12 主持

国家自然科学基金面上项目：抗胰腺癌天然产物majusculamide D的构效关系研究2021.1-2024.12 主持

天津市创新人才推进计划优秀青年科技人才

BETVLCTOR伟德在线登录平台百名青年学科带头人

王良从事复杂天然产物全合成，基于天然产物结构的药物化学和靶点探索研究。王良已指导学生完成了21个复杂天然产物的全合成，针对肾纤维化、胰腺癌、肝癌、结肠癌、急性肺损伤的治疗提供了多个以天然产物为模板的小分子实体。以防风草内酯（ovatodiolide）为模板，具体指导学生研发的1个抗肾纤维化候选药物现已完成规范化的临床前研究，批发达国家临床I期伦理，并已入组临床I期患者。同时，以天然产物为模板，基于构效关系，设计了多个活性分子探针，为新靶点的探索提供了分子工具，并合作发现共价抗癌新靶点。

王良以通讯作者（含共）、第一作者在Angew. Chem. Int. Ed.（6篇）、Nat. Comm.（1篇，最后通讯作者）、Chem. Sci.(1篇)、J. Med. Chem.（2篇）、Org. Lett.（3篇）、Chem. Comm.（1篇）等杂志发表论文20余篇。

1. Bolin Chen, Qianwei Wu, Dongdong Xu, Xijing Zhang, Yahui Ding, Shiqi Bao, Xuemei Zhang, Liang Wang,* Yue Chen.* A Two-phase Approach to Fusicoccane Synthesis to Uncover a Compound That Reduces Tumourigenesis in Pancreatic Cancer Cells. Angew. Chem. Int. Ed. 2022, 61, e202117476.

2. Jianshuang Guo, Juanjuan Li, Zehan Wang, Yang Liu, Yuxin Yue, Huabin Li, Xiuhe Zhao, Yuanjun Sun, Yahui Ding, Fei Ding, Dongsheng Guo,* Liang Wang,* Yue Chen. Dual Hypoxia-Responsive Supramolecular Complex for Cancer Target Therapy. Nat. Comm. 2023, 5634.

3. Sen Zhang, Songming Zhang, Yunlong Fan, Xuhan Zhang, Jing Chen, Chaofan Jin, Sisi Chen, Liang Wang,* Quan Zhang,* Yue Chen.* Total Synthesis of the Proposed Structure of Neaumycin B. Angew. Chem. Int. Ed. 2023, e202313186.

4. Junhong Xiang, Yahui Ding,* Jiaxin Li, Xiuhe Zhao, Yuanjun Sun, Da Wang, Liang Wang,* Yue Chen.* Ovatodiolides: Scalable Protection-Free Syntheses, Configuration Determination and Biological Evaluation against Hepatic Cancer Stem Cells. Angew. Chem. Int. Ed. 2019, 58, 10587-10590.

5. Can Liu, Liang Wang,* Yuanjun Sun, Xiuhe Zhao, Tianyang Chen, Xiuwen Su, Hui Guo, Qin Wang, Xiaonan Xi, Yahui Ding,* Yue Chen.* Probe Synthesis Reveals Eukaryotic Translation Elongation Factor 1 Alpha 1 as the Anti-Pancreatic Cancer Target of BE-43547A2. Angew. Chem. Int. Ed. 2022, 61, e202206953.

6. Yuanjun Sun#, Yahui Ding#, Dongmei Li, Ruifei Zhou, Xiuwen Su, Juan Yang, Xiaoqian Guo, Chuanke Chong, Jinghan Wang, Weicheng Zhang, Cuigai Bai, Liang Wang,* Yue Chen.* Cyclic Depsipeptide BE-43547A2: Synthesis and Activity against Pancreatic Cancer Stem Cells. Angew. Chem. Int. Ed. 2017, 56, 14627-14631.

7. Liang Wang, Hengtao Wang, Yi Hang Li, and Pingping Tang*, Total Synthesis of Schilancitrilactones B and C. Angew. Chem. Int. Ed. 2015, 54, 5732. 

8. Bolin Chen, Xijing Zhang, Yufen Yang, Dongdong Xu, Qianwei Wu, Shibo Wang, Shiqi Bao, Xuemei Zhang, Yahui Ding,* Liang Wang,* Yue Chen.*  Hypocretenolides: Collective Total Syntheses and Activities toward Metastatic Colon Cancer, Chem. Sci. 2024, 15, 6397-6401.

9. Yingjun Cui, Mengyi Zhang, Honglei Xu, Tingrong Zhang, Songming Zhang, Xiuhe Zhao, Peng Jiang, Jing Li,* Baijun Ye, Yuanjun Sun, Mukuo Wang, Yangping Deng, Qing Meng, Yang Liu, Qiang Fu, Liang Wang,* Yue Chen.* Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo Biological Evaluation for Acute Lung Injury. J. Med. Chem. 2022, 65, 2971-2987.

10. Jinghan Wang, Beijia Kuang, Xiaoqian Guo, Jianwei Liu, Yahui Ding, Jiangnan Li, Shende Jiang, Ying Liu, Fang Bai, Luyuan Li, Quan Zhang, Xiao-Yu Zhu, Bo Xia, Chun-Qi Li, Liang Wang,* Guang Yang,* Yue Chen.* Total Syntheses and Biological Activities of Vinylamycin Analogs. J. Med. Chem. 2017, 60, 1189-1209.

已协助指导硕士研究生9名，博士研究生4名。