王宝雷
王宝雷
博士 副研究员
王宝雷,博士,副研究员,元素有机化学研究所,毕业于BETVLCTOR伟德在线登录平台,安徽宿县砀山县人。
工作内容:教学科研
人才称号:
通讯地址:天津市卫津路94号BETVLCTOR伟德在线登录平台元素有机化学研究所六教405室
电 话:18920020912
电子邮件:nkwbl@nankai.edu.cn
课题组网站:
研究领域:有机化学,农药学
教育及科研经历:

2001年在BETVlCTOR登录网站元素有机化学研究所攻读农药学专业博士学位,师从李正名院士,2004年7月博士毕业留校任教。2015-2016年受国家公派赴加拿大University of Alberta作访问学者,师从Frederick G. West教授进行环状联烯和Nazarov电环化领域的有机合成方法学研究。任教以来,长期担任BETVLCTOR伟德在线登录平台本科生《有机化学》和《有机化学实验》课程的教学工作,并从事新农药创制的基础研究工作。科研工作主要致力于具有生物活性物质的分子设计、有机合成及构效关系研究。曾主持并完成国家自然科学基金、国家重点研发计划子课题、高等学校博士学科点专项科研基金各1项,天津市自然科学基金2项;曾参加国家“863”计划,“973”计划,中澳国际合作项目,国家自然科学(重点)基金,天津大学/BETVLCTOR伟德在线登录平台联合项目,美国DOW化学公司以及Aberjona公司的合作研发项目等多个课题的工作。目前主持国家自然科学基金面上项目课题2项。至今已发表论文60篇,申请发明专利15项。现为“Chin. Chem. Lett.”杂志青年编委,“J. Agric. Food Chem.”、“Pest Manag. Sci.”、“Phosphorus Sulfur Silicon Relat. Elem.”、“有机化学”等杂志审稿人。

荣誉和奖励

2012年,浙江省高校优秀科研成果二等奖

科研成果与代表作

部分发表的文章如下:

[35] Huan Li, Hang Liu, Yan Zhang, Na Yang, Lixia Xiong, Zhengming Li, Baolei Wang*. Synthesis, insecticidal activities, and SAR studies of novel piperazine-containing heterocyclic mono-/di-/tri-amide derivatives. Chin. Chem. Lett., 2021, 32, doi: https://doi.org/10.1016/j.cclet.2021.02.002.

[34] Baolei Wang, Marius-Georgian Constantin, Simarpreet Singh, Yuqiao Zhou, Rebecca L. Davis*, F. G. West*. Generation and trapping of electron-deficient 1,2-cyclohexadienes. Unexpected hetero-Diels–Alder reactivity. Org. Biomol. Chem., 2021, 19: 399-405.

[33] Yan Zhang, Junfeng Shang, Huan Li, Hang Liu, Haibin Song, Baolei Wang*, Zhengming Li*. Synthesis of novel N-pyridylpyrazole derivatives containing 1,2,4-oxadiazole moiety via 1,3-dipolar cycloaddition and their structures and biological activities. Chin. Chem. Lett., 2020, 31: 1276-1280.

[32] Baolei Wang*, Hongxue Wang, Hang Liu, Lixia Xiong, Na Yang, Yan Zhang, Zhengming Li*. Synthesis and structure-insecticidal activity relationship of novel phenylpyrazole carboxylic acid derivatives containing fluorine moiety. Chin. Chem. Lett., 2020, 31: 739-745.

[31] Bao-Lei Wang*, Hong-Wei Zhu, Zheng-Ming Li, Xiao Zhang, Shu-Jing Yu, Yi Ma, Hai-Bin Song. One-Pot Synthesis, Structure and Structure-Activity Relationship of Novel Bioactive Diphenyl/Diethyl(3-Bromo-1-(3-Chloropyridin-2-yl)-1H-Pyrazol-5-yl)(Arylamino)Methylphosphonates. Pest Manag. Sci., 2019, 75: 3273-3281.

[30] Yan Zhang, Zhengming Li, Haibin Song, Baolei Wang*. Synthesis, Structure and Biological Activities of Novel 2-(Trifluoromethyl)-6- arylimidazo[2,1-b][1,3,4]-thiadiazole (bis-)Mannich Base Derivatives Containing Substitutedpiperazine Moiety. Chin. J. Chem., 2018, 36: 635-638.

[29] Qiao-Xia Liu, Bao-Lei Wang*, Ming-Zhen Mao, Li-Xia Xiong, Zheng-Ming Li. Synthesis and pesticidal activities of novel anthranilic diamides containing pyridylpyrazole and iminodithiocarbamate or thiosemicarbazone motifs. Phosphorus Sulfur Silicon Relat. Elem., 2018, 193(9): 593-599.

[28] Bao-Lei Wang*, Hong-Wei Zhu, Zheng-Ming Li, Li-Zhong Wang, Xiao Zhang, Li-Xia Xiong, Hai-Bin Song. Synthesis, Biological Evaluation and SAR Analysis of Novel Poly Heterocyclic Compounds Containing Pyridylpyrazole Group. Pest Manag. Sci., 2018, 74: 726-736.

[27] Bao-Lei Wang*, Li-Yuan Zhang, Xing-Hai Liu, Yi Ma, Yan Zhang, Zheng-Ming Li*, Xiao Zhang. Synthesis, biological activities and SAR studies of new 3-substitutedphenyl-4-substitutedbenzylideneamino-1,2,4-triazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors. Bioorg. Med. Chem. Lett., 2017, 27: 5457-5462.

[26] Bao-Lei Wang*, Yan Zhang, Xing-Hai Liu, Li-Yuan Zhang, Yi-Zhou Zhan, Xiao Zhang, Li-Zhong Wang, Yong-Hong Li, Zheng-Ming Li*. Synthesis and biological activity of novel dimethylpyrazole and piperazine-containing (bis)1,2,4-triazole derivatives. Phosphorus Sulfur Silicon Relat. Elem., 2017: 192, 34-41.

[25] Bao-Lei Wang, Yan-Xia Shi, Shu-Jun Zhang, Yi Ma, Hong-Xue Wang, Li-Yuan Zhang, Wei Wei, Xing-Hai Liu, Yong-Hong Li, Zheng-Ming Li*, Bao-Ju Li*. Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties. Eur. J. Med. Chem., 2016, 117: 167-178.

[24] Bao-Lei Wang*, Li-Yuan Zhang, Yi-Zhou Zhan, Yan Zhang, Xiao Zhang, Li-Zhong Wang, Zheng-Ming Li*. Synthesis and biological activities of novel 1,2,4-triazole thiones and bis(1,2,4-triazole thiones) containing phenylpyrazole and piperazine moieties. J. Fluorine Chem., 2016, 184: 36-44.

[23] Yan Zhang, Xing-Hai Liu, Yi-Zhou Zhan, Li-Yuan Zhang, Zheng-Ming Li, Yong-Hong Li, Xiao Zhang, Bao-Lei Wang*. Synthesis and biological activities of novel 5-substituted-1,3,4-oxadiazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors. Bioorg. Med. Chem. Lett., 2016, 26: 4661-4665.

[22] Bao-Lei Wang*, Yi-Zhou Zhan, Li-Yuan Zhang, Yan Zhang, Xiao Zhang, Zheng-Ming Li*. Synthesis and fungicidal activities of novel 1,2,4-triazole thione derivatives containing 1,2,3-triazole and substituted piperazine moieties. Phosphorus Sulfur Silicon Relat. Elem., 2016, 191: 48-54.

[21] Li-Yuan Zhang, Bao-Lei Wang*, Yi-Zhou Zhan, Yan Zhang, Xiao Zhang, Zheng-Ming Li*. Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives. Chin. Chem. Lett., 2016, 27: 163-167.

[20] Li-Yuan Zhang, Bao-Lei Wang*, Yi-Zhou Zhan, Xue-Wen Hua, Ming Liu, Xiao Zhang, Hai-Bin Song, Zheng-Ming Li*. Synthesis and biological activity of novel N-glucosides containing substituted piperazine moiety. Lett. Drug Des. Discov., 2016, 13 (4): 343-351.

[19] Yizhou Zhan, Baolei Wang*, Liyuan Zhang, Yan Zhang, Xiao Zhang, Zhengming Li*, Haibin Song. Studies on the Synthesis, Structure and Biological Activities of Novel Arylaminoformyl-containing 1-Cyano-1-cycloproane Carboxylic Acid Amides Based on Ugi Reaction. Acta Chim. Sinica, 2015, 73, 1173-1181.

[18] Baolei Wang, Yanxia Shi, Yizhou Zhan, Liyuan Zhang, Yan Zhang, Lizhong Wang, Xiao Zhang, Yonghong Li, Zhengming Li*, Baoju Li*. Synthesis and Biological Activity of Novel Furan/Thiophene and Piperazine-Containing (Bis)1,2,4-triazole Mannich Bases. Chin. J. Chem., 2015, 33(10): 1124-1134.

[17] Bao-Lei Wang*, Jing Wu, Qiao-Xia Liu, Yong-Hong Li, Hai-Bin Song, Zheng-Ming Li*. Synthesis, structure, and biological activities of [5-(arylthio/sulfinyl/sulfonyl)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-arylmethanones. Phosphorus Sulfur Silicon Relat. Elem., 2015, 190(1): 66-78.

[16] Bao-Lei Wang*, Qing-Nan Li, Yi-Zhou Zhan, Li-Xia Xiong, Shu-Jing Yu, Zheng-Ming Li*. The synthesis and biological activities of [5-(4-substituted phenylsulfinyl/sulfonyl)-1,3-dimethyl-1H-pyrazol-4-yl]-arylmethanones. Phosphorus Sulfur Silicon Relat. Elem., 2014, 189: 483-491.

[15] Bao-Lei Wang, Hong-Wei Zhu, Yi Ma, Li-Xia Xiong, Yong-Qiang Li, Yu Zhao, Ji-Feng Zhang, You-Wei Chen, Sha Zhou, Zheng-Ming Li*. Synthesis, Insecticidal Activities, and SAR Studies of Novel Pyridylpyrazole Acid Derivatives Based on Amide Bridge Modification of Anthranilic Diamide Insecticides. J. Agric. Food Chem., 2013, 61: 5483-5493.

[14] Zhang, Ji-Feng ; Liu, Chen; Ma, Yi; Wang, Bao-Lei*; Xiong, Li-Xia; Yu, Shu-Jing; Li, Zheng-Ming*. Synthesis of Novel 3-Chloropyridin-2-yl-Pyrazole Derivatives and their Insecticidal, Fungicidal Activities and QSAR Study. Lett. Drug Des. Discov., 2013, 10(6): 497-506.

[13] Wang Baolei, Ma Yi, Xiong Lixia, Li Zhengming. Synthesis and Insecticidal Activity of Novel N-Pyridylpyrazole Carbonyl Thioureas. Chin. J. Chem., 2012, 30: 815-821.

[12] Ji-Feng Zhang, Jun-Ying Xu, Bao-Lei Wang, Yu-Xin Li, Li-Xia Xiong, Yong-Qiang Li, Yi Ma, Zheng-Ming Li. Synthesis and Insecticidal Activities of Novel Anthranilic Diamides Containing Acylthiourea and Acylurea. J. Agric. Food Chem., 2012, 60: 7565-7572.

[11] Wang Bao-Lei, Liu Xing-Hai, Zhang Xiu-Lan, Zhang Ji-Feng, Song Hai-Bin, Li Zheng-Ming*. Synthesis, Structure and Biological Activity of Novel 1,2,4-Triazole Mannich Bases Containing a Substituted Benzylpiperazine Moiety. Chem. Biol. Drug Des., 2011, 78: 42-49.

[10] Wang, Bao-Lei; Shi, Yan-Xia; Ma, Yi; Liu, Xing-Hai; Li, Yong-Hong; Song, Hai-Bin; Li, Bao-Ju*; Li, Zheng-Ming*. Synthesis and Biological Activity of Some Novel Trifluoromethyl-Substituted 1,2,4-Triazole and Bis(1,2,4-Triazole) Mannich Bases Containing Piperazine Rings. J. Agric. Food Chem., 2010, 58(9): 5515-5522.

[9] Wang, B. L.; Ma, R. D.; Li, Y. H.; Song, H. B.; Li, Z. M. Synthesis, Structure and Biological Activity of 2- 4-(5-Substituted-1,3,4-oxadiazol-2-yl)phenoxy Propanoate/Acetate. Chin. J. Org. Chem., 2010, 30(1): 92-97. 

[8] Wang, B. L.; Liu, X. H.; Li, Z. M., Synthesis and Characterization of O,O-Dimethyl-N-(2,2,2-trichloro- 1-arylaminoethyl) Phosphoramidothioates. Phosphorus Sulfur Silicon Relat. Elem., 2009, 184(9): 2281-2287. 

[7] Bao-Lei Wang, Yong-Hong Li, Jian-Guo Wang, Yi Ma, Zheng-Ming Li. Molecular design, synthesis and biological activities of amidines as new ketol-acid reductoisomerase inhibitors. Chin. Chem. Lett., 2008, 19: 651-654.

[6] WANG Bao-Lei, LI Zheng-Ming, LI Yong-Hong, WANG Su-Hua. Synthesis and Herbicidal Activities of 4-Alkoxy/benzyloxyphenyltetrazoles and 1,3,4-Oxadiazoles. Chem. J. Chin. U., 2008, 29(1): 90-94.

[5] Bao-Lei Wang, Zheng-Ming Li, Yong-Hong Li, Su-Hua Wang. Syntheses and biological activities of ethyl N-hydroxy-N-(substituted)phenyloxamates as KARI inhibitors. Chem. Res. Chin. U., 2007, 23(3): 280-283.

[4] Bao-Lei Wang, Ronald G Duggleby, Zheng-Ming Li, Jian-Guo Wang, Yong-Hong Li, Su-Hua Wang, Hai-Bin Song. Synthesis, crystal structure and hebricidal activity of mimics of intermediates of the KARI reaction. Pest Manag. Sci., 2005, 61: 407-412.

[3] WANG Bao-Lei, WANG Jian-Guo, MA Yi, LI Zheng-Ming, LI Yong-Hong, WANG Su-Hua. Molecular Docking and 3D-QSAR Research of Amidines of KARI Inhibitor. Acta Chimica Sinica, 2006, 64(13): 1373-1378.

[2] WANG Bao-Lei, LI Zheng-Ming, MA Yi, WANG Jian-Guo, LUO Xiao-Min, ZUO Zhi-Li. 3D-Database Searching Based on the Crystal Structure of Ketol-acid Reductoisomerase (KARI) Complex. Chin. J. Org. Chem., 2004, 24(8): 973-976.

[1] Wang Bao-Lei, Ma Ning, Wang Jian-Guo, Ma Yi, Li Zheng-Ming, Li Yong-Hong. 3D-QSAR Analysis of New Sulfonylureas Related to Their Herbicidal Activity. Acta Physico-chimica Sinica, 2004, 20(6): 577-581.

部分授权专利如下:

[5] 1,2,4-三唑环并[4,3-a]稠合哌嗪的曼尼希碱类衍生物及其制备方法和应用. 中国发明专利, 授权号: ZL201610993675.X, 申请日: 2016年11月11日, 授权日: 2019年03月19日.

[4] 含三氟甲基和哌嗪的三唑Mannich碱类化合物及其制备与应用. 中国发明专利, 授权号: ZL201510603487.7, 申请日: 2015年09月17日, 授权日: 2019年03月05日.

[3] 含(杂)芳基和哌嗪的1,2,4-三唑硫酮衍生物及制备方法和应用. 中国发明专利, 授权号: ZL201510603490.9, 申请日: 2015年09月17日, 授权日: 2018年05月01日.

[2] 含哌嗪的1,3,4-噁二唑Mannich碱类化合物及制备与应用. 中国发明专利, 授权号: ZL201610039702.X, 申请日: 2016年01月20日;授权日: 2017年09月12日.

[1] 吡唑甲酰基硫脲衍生物与制备方法和应用. 中国发明专利, 授权号: ZL201110147505.7, 申请日: 2011年06月02日; 授权日: 2013年11月06日.

人才培养

指导研究生(含协助李正名院士指导硕博士生)已毕业17人。

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